Our Newsletter

Concluded Grants

 

 USC logo Emotional behavior and brain connectivity in adolescents with Congenital Adrenal Hyperplasia (CAH).

M. Herting PI, USC Provost Postdoctoral Scholar Research Grant, Sowell Mentor, 2014-2015

Congenital Adrenal Hyperplasia (CAH), a genetic disorder involving abnormal steroid production, is characterized by excessive prenatal testosterone exposure from as early as the first trimester. In the current study, CAH is used as a natural model for determining how fetal testosterone levels impact sexual differentiation of amygdala neural circuitry.

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Longitudinal Examination of Human Amygdala-VMPFC Development

R01 MH091864-03, NIMH, Sowell Consultant, 2010–2015.

The primary objective of this application is to longitudinally examine the structural and functional development of the human amygdala and the emergence of its connections with the ventromedial prefrontal cortex (vmPFC) as children age into adolescence.

2010 – 2015

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Pediatric Template of Brain Perfusion

NIMH (Sowell Co-I) 3R01MH080892-01A2S1

We propose “An Integrated Pediatric Template of Brain Structure and Function” – a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation.

2010 – 2014

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Pediatric Template of Brain Perfusion

NIMH (Sowell Co-I) 3R01MH080892-01A2S1

We propose “An Integrated Pediatric Template of Brain Structure and Function” – a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation.

2010 – 2014

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Reconnection of Neural Networks and Cognitive Recovery After Pediatric TBI

NICHD (Sowell Co-I) 1R01HD061504-01A1

Innovative brain imaging and behavioral neuroscience methods will be used to assess changes in brain structure and function following pediatric TBI. By explicating mechanisms that underlie naturally-occurring white matter injury and repair, the proposed project will identify potential new targets for interventions designed to accelerate the process of neurocognitive recovery.

2010 – 2015

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Pediatric AIDS/HIV Cohort Study (PHACS II)

NICHD (Sowell Subcontract PI) 5U01 HD052104-05

This is a multi-site, multidisciplinary study evaluating the effects of perinatal HIV transmission from mother to fetus, and/or the effects of antiretroviral drug regimens on medical and cognitive development during childhood and adolescence.
ABSTRACT

2009 –  2013 | $15,921

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Imaging Brain Maturation and Neurobehavioral Correlates

K01-01733, NIMH (Sowell PI)

The goal of this study is to localize and stage maturational brain changes between childhood and adolescence using structural and functional magnetic resonance imaging (MRI) and to relate these changes to improving cognitive abilities assessed with cognitive psychological tests of learning and memory and functional MRI.

2000 – 2004 | $140,000

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UCLA Child and Adolescent Psychiatry

NIMH Research Fellow
UCLA Child and Adolescent Psychiatry

1997 – 1999

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Pediatric Study Centers (PSCs) For a MRI Study of Normal Brain Development

NINDS N01-NS-9-2315 (McCracken PI)

Pediatric Study Centers (PSCs) For a MRI Study of Normal Brain Development

1999 – 2005

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March of Dimes Basil O’Connor Starter Scholar Research Award

#5-FY93-12 (Sowell PI)

fMRI in regions of structural abnormality in children and adolescents: Mapping the teratogenic effects of prenatal alcohol exposure

2003 – 2006 | $68,000

 NIDA

Analyzing Functional and Structural MRI in FAS Children

R21-DA015878-01, NIDA (Sowell PI)

The goal is to understand better the effects of severe prenatal alcohol exposure on the structure and function of the developing human brain by using advanced image analysis technology to combine functional and structural magnetic resonance imaging data.

2002 – 2005 | $300,000

 Print

Cross-cultural FASD: Brain Imaging (U24 Core)

1U24AA014808-01, NIAAA (Sowell PI)

The goal of this brain imaging core is to better understand the effects of prenatal alcohol exposure on the developing brain by facilitating the use of advanced brain image processing tools among an international consortium of fetal alcohol spectrum disorder (FASD) researchers.

2003 – 2007 | $152,217

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Mapping Language Development Longitudinally

U54 RR021813, NCRR (Sowell Co-I)

The overarching goal of the proposed studies is to longitudinally investigate the functional and behavioral significance of structural brain change recently observed in classical brain language regions during the process of normal development.

2004 – 2007 | $175,000

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Longitudinal MRI in Prenatal Methamphetamine or Alcohol Exposure

R01 DA017831, NIDA (Sowell PI)

The goal is to understand the effects of prenatal methamphetamine or alcohol exposure in the developing human brain using functional and structural magnetic resonance imaging and a longitudinal study design.

ABSTRACT

2004 – 2009 | $352,038

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Adolescent Literacy: Classification, Mechanism, Outcomes

R01 HD046171-01 (Shaywitz PI), NICHD (Sowell Subaward PI)

We propose to focus on the discovery of cognitive, behavioral, and neurobiological mechanisms underlying adolescent literacy that can facilitate identification, prevention and remediation of adolescent reading difficulties.

2004 – 2009 | $35,503 Sub Award

NIDA

Pubertal Brain Maturation & Drug Use Vulnerability

R01 DA018910 (Dahl PI), NIDA (Sowell Subaward PI)

The goal is to assess the neural basis for affective changes during pubertal maturation with an emphasis on sensation-seeking, reward-seeking, and risk-taking relevant to understanding adolescent vulnerability to substance use disorders.

2004 – 2009 | $55,617 Sub Award

 NIDA

Longitudinal MRI in Prenatal Methamphetamine or Alcohol Exposure

NIDA Renewal of NIDA R01 DA017831 (Sowell PI)

Longitudinal MRI in Prenatal Methamphetamine or Alcohol Exposure

ABSTRACT

2011 – 2016

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Mapping the Effects of Severe Prenatal Alcohol Exposure on Brain Function-Structure Relationships Using DTI and fMRI

March of Dimes 6-FY2008-50 Renewal (Sowell PI)

Mapping the effects of severe prenatal alcohol exposure on brain function-structure relationships using DTI and fMRI.

2011 – 2014

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Tourette Syndrome Association Neuroimaging Consortium

WU-12-40-MOD-2 NCTE, Washington Univ. via Tourette Syndrome Association,Inc. Sowell Sub-award PI

The major goals of this project are to develop and implement structural brain image analysis software that will be used to conduct structural MRI data analysis and to assess relationships between cortical thickness, regional brain volumens, and connectivity in individuals with Tourette syndrome compared to typically developing individuals. Similar methods can be used to evaulate relationships between brain morphology and symptom severity within the Tourette group.

2011-2013 | $ 14,001 (sub-award)

 march_of_dimes_stacked_logo1 Mapping the effects of severe prenatal alcohol exposure on brain function-structure relationships using DTI and fMRIMarch of Dimes

#6-FY08-562 NCTE (Sowell PI)

The overarching goal of this study is to better understand the effects of severe prenatal alcohol exposure on relationships between brain function and white matter integrity using functional MRI and DTI.

2008–2013 | $93,497

 NIDA Creating a Pediatric Imaging-Genomics Data Resource,

RC2 DA029475 NCTE, NIDA (Sowell Subaward PI)

The major goals of this project is to assemble a large, cross-sectional imaging-genomics dataset to be used as a shared resource for investigations of genetic bases of neural phenotypes and age-by-genotype interactions that may represent genetically-mediated differences in developmental trajectories.

2009–2013 | $21,000 (sub award)

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Mapping the Effects of Severe Prenatal Alcohol Exposure on Brain Function-Structure Relationships Using DTI and fMRI

March of Dimes 6-FY2008-50 (Sowell PI)

The overarching goal of this study is to better understand the effects of severe prenatal alcohol exposure on relationships between brain function and white matter integrity using functional MRI and DTI.

2008 – 2013 | $ 93,497

 nimhlogo Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence (Administrative Supplement)

R01 MH087563-03S2, NIMH (Sowell PI)

The purpose of this administrative supplment is to evaluate structural and functional connections between brain regions important for processing risk and reward by adding resting state fMRI to our battery of image acquisition modalities. Further, we propose to expand image analyses to evaluate connectivity in both DTI and rs-fMRI using sophisticated analyses. All of these goals can be accomplished by integrating data collected as part of the parent grant with data to be collected as part of this administrative supplement.

2012-2013 | $ 77,503

NIDA

Brain Development, Behavior and Cognition in Pre- and Postnatal Cocaine Exposure

NIDA (Sowell Co-PI) R21 DA027561

Secondary data analysis grant to analyze two sets of brain MRI, behavioral and neuropsychological data collected from children/adolescents enrolled in a prospective, longitudinal study of prenatal cocaine exposure (Project CARE).

2009 – 2013 | $21,000 (sub-award)

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Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence (Adminstrative Supplement)

R01 MH087563-03S2, NIMH (Sowell PI)

The purpose of this administrative supplment is to evaluate structural and functional connections between brain regions important for processing risk and reward by adding resting state fMRI to our battery of image acquisition modalities. Further, we propose to expand image analyses to evaluate connectivity in both DTI and rs-fMRI using sophisticated analyses. All of these goals can be accomplished by integrating data collected as part of the parent grant with data to be collected as part of this administrative supplement.

2012-2013 | $77,503

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Pediatric AIDS/HIV Cohort Study (PHACS II) Brain Imaging Pilot

U01 HD052104-08, NICHD (Sowell Subaward PI)

Pilot brain imaging study in the Chicago PHACS AMP cohort: The effects of in utero HIV infection on adolescent brain development. The overarching goals of this pilot project are to investigate the impact of perinatal HIV infection and long-term ART exposure on childhood and adolescent brain development and its relation to cognitive function and HIV disease status biomarkers using multi-modal magnetic resonance imaging (structural MRI, DTI, resting state fMRI) in the Chicago PHACS AMP cohort.

2011- 2013 | $ 63,000 

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Pediatric AIDS/HIV Cohort Study (PHACS II)

NICHD (Sowell Subcontract PI) 5U01 HD052104-05

This is a multi-site, multidisciplinary study evaluating the effects of perinatal HIV transmission from mother to fetus, and/or the effects of antiretroviral drug regimens on medical and cognitive development during childhood and adolescence.
ABSTRACT

2009 – 2013 | $15,921

 nichd_logo Pediatric AIDS/HIV Cohort Study (PHACS II) Brain Imaging Pilot

U01 HD052104, NICHD (Sowell Subaward PI)

Pilot brain imaging study in the Chicago PHACS AMP cohort: The effects of in utero HIV infection on adolescent braindevelopment. The overarching goals of this pilot project are to investigate the impact of perinatal HIV infection and long-term ART exposure on childhood and adolescent brain development and its relation to cognitive function and HIV disease status biomarkers using multi-modal magnetic resonance imaging (structural MRI, DTI, resting state fMRI) in the Chicago PHACS AMP cohort.

2011–2013 | $63,000

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Longitudinal Mapping of Maturational Change in Brain Function-Structure Relationships

NICHD R01 HD053893-01 (Sowell PI)

The overarching goal of the proposed studies is to longitudinally investigate the functional and behavioral significance of structural change in the form of gray matter thickness increases recently observed in classical brain language regions during the process of normal development.
ABSTRACT

2007 – 2013 | $ 371,174